Abstract #1383

In vivo mapping of the intra-cortical vasculature and layer-specific changes in Δχ and ΔR2* of human cerebral cortex using USPIO-MRI at 7T

Chenyang Li^1,2,3, Yongsheng Chen⁴, Sagar Buch⁴, Zhe Sun^1,2,3, Li Jiang^1,2, Marco Muccio^1,2, E. Mark Haacke^4,5, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁴Department of Neurology, Wayne State University School of Medicine, Detroit, MI, United States, ⁵Department of Radiology, Wayne State University School of Medicine, Detroit, MI, United States

Synopsis

Keywords: Blood Vessels, Blood vessels

Motivation: In vivo imaging of intra-cortical vessels of human brain, including penetrating arteries, veins and capillary density are still scarce.

Goal(s): To reconstruct the in vivo intra-cortical vessels of the human brain and estimate the cortical layer-specific changes in susceptibility (χ) in the presence of superparamagnetic iron oxides.

Approach: With aid of Ferumoxytol at 7T, high resolution gradient echo imaging was implemented to reconstruct pre-/post-SWI, R2* and χ maps.

Results: Intra-cortical penetrating arteries and veins can be differentiated by pre- and post-contrast SWI. Changes in R2* and χ revealed variations reflective of capillary density across different layers, which is in agreement with histological findings.

Impact: This study provides in vivo imaging characterization of intra-cortical vessels of human brain using high-resolution Ferumoxytol-enhanced SWI at 7T. Utilizing changes in R2* and χ enables us delve deeper into the laminar distribution of capillary density across various cortical layers.

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