Abstract #1474

The relationship of intracellular sodium fraction and pharmacokinetics in breast cancer

Joshua D Kaggie¹, Otso Arponen¹, Mary A McLean¹, Muzna Nanaa¹, Roido Manavaki¹, Gabrielle C Baxter¹, Andrew B Gill¹, Jonathan Birchall¹, Frank Riemer², Aneurin Kennerley^3,4, Ramona Woitek¹, William J Brackenbury^4,5, and Fiona J Gilbert¹

¹Radiology, University of Cambridge, Cambridge, United Kingdom, ²Mohn Medical Imaging and Visualization Centre (MMIV), Haukeland University Hospital, Bergen, Norway, ³Institute of Sport, Department of Sport and Exercise Science, Manchester Metropolitan University, Manchester, United Kingdom, ⁴Biology, University of York, York, United Kingdom, ⁵York Biomedical Research Institute, University of York, York, United Kingdom

Synopsis

Keywords: Breast, Cancer, sodium, breast, inversion recovery, DCE-MRI

Motivation: Breast cancer MRI has high sensitivity but has an unmet need for increased specificity. Sodium MRI has the potential to improve tumor characterisation and thus treatments.

Goal(s): To determine whether there is a relationship between tissue permeability by correlating intracellular sodium fraction with pharmacokinetic parameters.

Approach: Conventional DCE-MRI parameters were acquired as well as intracellular sodium fraction maps (= inversion recovery sodium / total sodium concentration) in 17 breast cancer lesions (grade 1:n=3; grade 2: n=9; grade 3:n=7).

Results: The fraction of intracellular sodium to total sodium concentration had significant correlations (p-values <0.11) with K_trans and k_ep, and with cancer grade.

Impact: Breast cancer imaging has an unmet need to differentiate ductal carcinoma from benign and invasive lesions. Sodium MRI can provide intra- and extra-cellular sodium measurements, which may improve lesion differentiation by using endogenous contrast.

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