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Abstract #1513

Quantitative Myocardial MR Perfusion: Accurate Delay Estimation through Deep-Learning based Outlier Detection

Sherine Brahma1, Andreas Kofler1, Tobias Schaeffter1,2,3, Amedeo Chiribiri2, and Christoph Kolbitsch1,2
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2School of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom, 3Department of Biomedical Engineering, Technical University of Berlin, Berlin, Germany

Synopsis

Keywords: Myocardium, Perfusion

Motivation: While extensive research has explored robust pixel-wise quantification of myocardial blood flow, there is also a need for further investigation into accurate myocardial signal delay estimation, given its diagnostic value, for enhancing conventional clinical myocardial perfusion protocols.

Goal(s): We seek to address the primary challenges in calculating delay and improve its estimation accuracy.

Approach: We introduce a deep learning approach designed to recognize motion artifacts as outliers along the temporal signal curve of each voxel, subsequently eliminating them from the perfusion quantification process.

Results: Our findings suggest that eliminating outliers enhances the accuracy of perfusion delay parameter estimation in scenarios with residual motion.

Impact: Enhancing the precision of delay estimation will increase its diagnostic value as a biomarker, offering crucial insights into the identification of perfusion defects in ischemic hearts.

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