Abstract #1612

Detection of neuroinflammation and ischemia in traumatic brain injury in rats using amide proton transfer MRI

Yunfan Zou^1,2, Qianqi Huang³, Chongjun Yang⁴, Jingpu Wu⁵, Puyang Wang¹, Shanshan Jiang¹, and Jinyuan Zhou¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³Department of Computer Science, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁵Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Traumatic Brain Injury, Traumatic brain injury, neuroinflammation, ischemia

Motivation: Ischemia and neuroinflammation, two key endophenotypes post-TBI, are difficult to assess in vivo.

Goal(s): Our goal was to evaluate the feasibility of utilizing amide proton transfer-weighted (APTw) imaging as a biomarker for detecting neuroinflammation and ischemia post-TBI.

Approach: Brain APTw MRI signals of 55 rats subjected to a mild, moderate, or severe TBI were analyzed and compared to other criteria defining neuroinflammation and ischemia.

Results: The areas under curve (AUCs) of the ipsilateral cortex APTw signals at 3 days and 1 hour post-TBI were 0.725 for detecting neuroinflammation and 0.411 for detecting ischemia, respectively.

Impact: The feasibility of detecting neuroinflammation and ischemia using APTw MRI would improve the capability of MRI to objectively assess TBI and enable the accurate detection of these pathological processes at an early stage post-TBI.

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