Abstract #1827

Investigating Cortical Neurochemical Concentrations in Painful Knee Osteoarthritis using Magnetic Resonance Spectroscopy

Samantha A Leech^1,2,3,4,5, Marilena M DeMayo^3,4,5, Tiffany K Bell^3,4,5, Eldridge Batuyong^2,6, Marcia Clark⁶, Geoff Schneider³, Neil White^2,6, Kayla Millar⁵, Charley Hasselaar², Richard Ng^2,6, Sarah L Manske^1,2,3, and Ashley D Harris^3,4,5

¹Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, ²McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ³Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁵Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁶Section of Orthopaedic Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Spectroscopy, Osteoarthritis, Chronic Pain

Motivation: Alterations in the brain are suggested to contribute to chronic arthritis pain, however there is limited research on the specific neurochemicals and brain regions involved in this process.

Goal(s): We aimed to identify neurochemicals and brain regions associated with chronic pain in knee osteoarthritis to understand the brain’s contribution to this condition.

Approach: We used magnetic resonance spectroscopy to compare neurochemical levels in four pain-related brain regions between cohorts of patients with painful knee osteoarthritis and healthy controls.

Results: Significantly lower levels of GABA and myoinositol in the anterior cingulate cortex in the knee osteoarthritis group suggests potential disrupted inhibitory processes and neuroinflammation.

Impact: Patients with painful knee osteoarthritis exhibited significantly lower levels of GABA and myoinositol in the anterior cingulate cortex compared to healthy controls. These findings illuminate the anterior cingulate cortex as a potential therapeutic target for knee osteoarthritis pain management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.