Abstract #1846

Medium Term Reproducibility of 1H FID-CRT-MRSI at 7 Tesla

Philipp Lazen^1,2,3, Ahmet Azgın^1,2, Benjamin Spurny-Dworak^4,5, Lukas Hingerl², Bernhard Strasser², Wolfgang Bogner^2,3, Rupert Lanzenberger^4,5, Karl Rössler¹, Siegfried Trattnig^2,3,6, and Gilbert Hangel^1,2,3

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, ⁴Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria, ⁵Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria, ⁶Institute for Clinial and Molecular MRI, Karl Landsteiner Society, St. Poelten, Austria

Synopsis

Keywords: Spectroscopy, Brain, 7T, Neuro, MRSI, Reproducibility

Motivation: 1H FID-CRT-MRSI at 7T is a promising approach for non-invasive quantification of metabolic processes in the brain. Its medium-term reproducibility has never been investigated even though it is a requirement for many potential study setups.

Goal(s): To evaluate the intersession reproducibility of 1H FID-CRT-MRSI at 7T.

Approach: We calculated metabolite concentration estimates in 55 brain regions for two measurement sessions one week apart, and determined coefficients of variations between them.

Results: We found good overall reproducibility, with CVs ranging from 7.5% to 12% for different brain regions, and concentration estimates matching our previous work.

Impact: We established good reproducibility of FID-CRT-MRSI at 7T, enabling longitudinal study setups e.g. for disease monitoring. Another potential follow-up of this work may be tracking the intra-day metabolite level variations in the brain in a non-invasive way.

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