Keywords: Arterial Spin Labelling, Perfusion
Motivation: The high SAR burden of PCASL at 7T typically requires long TRs and short label durations, reducing SNR efficiency and perfusion measurement accuracy.
Goal(s): Our goal was to maximize the SNR efficiency of PCASL at 7T.
Approach: We optimized the PCASL B1+/gradient parameters and background suppression pulses to maximize SNR efficiency (i.e., balancing labeling efficiency and SAR), and utilized VERSE and dynamic B0 shimming to reduce SAR.
Results: Compared to optimizing the PCASL parameters for maximum labeling efficiency, our max-SNR efficiency optimized parameters increased SNR efficiency by 38% and reduced TRs by 41% in vivo.
Impact: The improved SNR efficiency of our optimized 7T PCASL parameters increases the advantages of ultra-high field perfusion measurements, enabling robust and high-SNR perfusion measurement in clinically viable scan times.
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