Keywords: White Matter, White Matter
Motivation: There is a need for selective myelin imaging with minimal contamination from long-T2 water components.
Goal(s): To develop a new contrast mechanism for direct visualization of myelin using a three-dimensional adiabatic inversion recovery prepared ultrashort echo time (3D IR-UTE) sequence.
Approach: We employed the long-T2 signal phase transition in 3D dual-echo IR-UTE imaging to find the optimal inversion time (TI) necessary to null water signals for selective myelin imaging in a clinical 3T scanner.
Results: Myelin signal could be selectively detected by 3D IR-UTE sequence based on long-T2 phase transition and optimal TI for both ex vivo and in vivo brains.
Impact: The 3D IR-UTE sequence allows direct imaging of myelin, which is important for accurate diagnosis and assessment of multiple sclerosis (MS), Alzheimer’s disease (AD), and other neurological diseases.
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