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Abstract #2178

Discrepancies between Magnetic Resonance Fingerprinting and other T1 and T2 mapping methods are microstructure dependent

Simran Kukran1,2, Joely Smith 1,3, Ben Statton4, Luke Dixon3,5, Stefanie Thust6,7,8, Iulius Dragonu9, Sarah Cardona3, Mary Finnegan3, Rebecca Quest1,3, Neal Bangerter1,10, Dow Mu Koh11, Peter Lally1, Matthew Orton11, and Matthew Grech Sollars12,13
1Bioengineering, Imperial College London, London, United Kingdom, 2Institute of Cancer Research, London, United Kingdom, 3Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 4London Institute of Medical Sciences, Medical Research Council, London, United Kingdom, 5Surgery and Cancer, Imperial College London, London, United Kingdom, 6Precision Imaging Beacon, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 7School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 8Dept. of Brian Rehabilitation and Repair, UCL Institute of Neurology, London, United Kingdom, 9Research and Collaborations UK, Siemens Healthcare Ltd, Camberley, United Kingdom, 10Computer and Electrical Engineering, Boise State University, Boise, ID, United States, 11Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom, 12Centre for Medical Imaging and Computing, UCL, London, United Kingdom, 13University College London Hospitals NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Relaxometry, MR Fingerprinting

Motivation: T1 and T2 accuracy in the brain is difficult to assess, since there is no ground truth available.

Goal(s): To investigate how well relaxometry methods agree.

Approach: We compare Magnetic Resonance Fingerprinting (MRF) T1 and T2 mapping with Variable Flip Angle (VFA) T1 mapping and Multi-Echo Spin Echo (T2) mapping in 11 anatomical brain regions for 10 healthy volunteers, and in the relevant spheres of the NIST phantom.

Results: MRF underestimates T1 and T2 in comparison with T1 VFA and T2 MESE in the human brain, especially in myelin-dense areas. Less T1 and no T2 bias is present in the NIST phantom.

Impact: Quantitative T1 and T2 relaxometry techniques are more consistent in the NIST phantom than the human brain. Deviations could be caused by magnetisation transfer, whose impact on T1 and T2 relaxation mechanisms needs further investigation.

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Abstract

Keywords