(ISMRM 2024) Evaluating the Impact of Glymphatic Clearance Dysfunction on Cognitive Function in Cerebral Small Vessel Disease
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Abstract #2190

Evaluating the Impact of Glymphatic Clearance Dysfunction on Cognitive Function in Cerebral Small Vessel Disease

Jie Yang1, Jianquan Zhong1, Rui Xiao1, Hengping Wu1, Chao Yuan1, Meining Chen2, and Feng Hao1
1Department of Radiology, First People's Hospital of Zigong City, Zigong, China, 2MR Research Collaboration, Siemens Healthineers, Chengdu, China

Synopsis

Keywords: Blood Vessels, Diffusion Tensor Imaging, cerebral small vessel disease; glymphatic clearance function; ALPS index; SVD score

Motivation: The pathogenesis of cerebral small vessel disease (SVD) is unclear, which may be related to glymphatic clearance.

Goal(s): To assess the association between glymphatic clearance function and the extent of cerebral damage in SVD, along with the effects on cognitive function.

Approach: We derived the ALPS index from DTI data to evaluate lymphatic function, and we utilized MR imaging to determine the SVD score as a measure of cognitive function.

Results: We found a significantly decrease in ALPS index in SVD patients compared to healthy controls, and a significantly negative correlation between the ALPS index in the left hemisphere and SVD severity.

Impact: Glymphatic clearance dysfunction may be present in patients with SVD and may be associated with decreased cognitive function.

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Keywords

indexalpsfunctionclearancepatientsdiseasecognitivecerebralvesseldiffusivityfibersdiffusionbrainassociation