Abstract #2202

Alterations of amide proton transfer weighted (APTw) signal after revascularization in patients with moyamoya disease

Chao Xia^1,2, Jiaxin Zeng^1,2, Hongxia Li¹, Xia Wei^1,2, Zhiqin Liu^1,2, Ziyu Li^1,2, Xing Li^1,2, Wei Yu^1,2, Yi Liu³, Kai Ai⁴, Na Hu^1,2, and Su Lui^1,2

¹Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, ³Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China, ⁴Philips Healthcare, Xi’an, China

Synopsis

Keywords: Blood Vessels, CEST & MT, Cerebrovascular disease

Motivation: Assessing alterations of the brain microenvironment in patients with moyamoya disease after revascularization (MMD) would develop optimal postoperative management and improve the prognosis.

Goal(s): This study aimed to explore alterations of amide proton transfer weighted (APTw) signal in patients with MMD after receiving revascularization surgery.

Approach: MMD patients who underwent unilateral revascularization surgery were prospectively collected. Baseline computed tomography perfusion (CTP) and APTw imaging were performed. Patients were followed up with CTP and APTw imaging about 1 year after revascularization.

Results: APTw values in both surgical and contralateral hemispheres at follow-up were found to be significantly higher than those at baseline.

Impact: APTw imaging is a potential assessment tool to quantitatively evaluate alterations of acid-base metabolism in the brain microenvironment of patients with MMD after revascularization, which provides additional information to help neurosurgeons develop optimal postoperative management and follow-up protocols for MMD.

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