Meeting Banner
Abstract #2326

Characterizing Cerebral Neurometabolic Changes in Diaschisis from Stroke using Fast 3D High-Resolution MRSI

Ziyu Meng1, Tianyao Wang2, Hong Zhou3, Chang Xu1, Bin Bo1, Yibo Zhao4,5, Yudu Li4,6, Wen Jin4,5, Zhi-Pei Liang4,5, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, Renji Hospital, Shanghai Jiao Tong University of Medicine, Shanghai, China, 3Department of Radiology, The First Affiliated Hospital of South China of University, South China of University, Hengyang, China, 4Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6The National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Stroke, Stroke

Motivation: Understanding metabolic changes in diaschisis is essential for stroke rehabilitation.

Goal(s): Our goal was to investigate the neurometabolite alterations in the disconnected white matter (WM) tracts and the downstream cortical gray matter (GM) regions, and their associations in early stroke outcome.

Approach: 3D 1H-MRSI scanning using SPICE technology (scan time: 8 minutes, resolution: 2×3×3 mm3, FOV: 240×240×72 mm3) was performed on 105 acute ischemic stroke patients.

Results: Our findings reveal a trend for decreased cortical GM NAA as the WM NAA in the diaschitic hemisphere decreases, both associated with early stroke outcome.

Impact: Using 3D high-resolution 1H-MRSI, we found a potential involvement of neuronal mitochondria metabolism in the metabolic changes observed in diaschisis from stroke. It may offer valuable prognostic biomarkers in stroke patients management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords