Abstract #2327

The effect of long label duration on hybrid multi-delay PCASL of time-encoded and variable-TR schemes in Moyamoya disease

Osamu Togao¹, Makoto Obara², Ryoji Mikayama³, Koji Yamashita⁴, Kazufumi Kikuchi¹, Tatsuhiro Wada³, Chiaki Tokunaga³, Shota Ishida⁵, Lena Vaclavu⁶, Matthias J.P. van Osch⁶, Kim van de Ven⁷, Marc Van Cauteren², and Kousei Ishigami⁴

¹Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Philips Japan, Tokyo, Japan, ³Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan, ⁴Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁵Department of Radiological Technology, Faculty of medical sciences, Kyoto College of Medical Science, Kyoto, Japan, ⁶C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁷Philips Healthcare, Best, Netherlands

Synopsis

Keywords: Stroke, Arterial spin labelling

Motivation: Accurate quantification of cerebral perfusion in Moyamoya disease using ASL is challenging.

Goal(s): To investigate the effect of long LD in hybrid multi-delay PCASL of time-encoded and variable TR schemes.

Approach: Patients with Moyamoya disease were scanned with hybrid schemes with respectively 12 delays obtained with LD of 2s (LD2s) and 9 delays obtained with LD of 3s (LD3s).

Results: The tSNR of LD3s was significantly higher than that of LD2s, especially in the regions with prolonged ATT. CBF measured by both methods showed a strong correlation, but the differences in CBF became larger for longer ATT.

Impact: The use of a long LD of 3s for hybrid multi-delay PCASL provides higher SNR compared to that of 2s, and may be useful for assessing cerebral perfusion with prolonged ATT as often seen in Moyamoya disease.

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