Keywords: Neonatal, Brain Connectivity, structure-function coupling
Motivation: Structure-function coupling (SFC) has been proposed to decode the relationship between anatomical structure and neural activity, but how SFC develops in the perinatal period remains largely unknown.
Goal(s): To establish typical SFC map at birth and portray its development during the perinatal period.
Approach: SFC of neonatal brains from 26 to 45 postmenstrual weeks were characterized using the dHCP data, and compared to that of adults. The developmental trajectories were depicted by GLM.
Results: SFC at birth already demonstrated a sensorimotor-to-association pattern but were immature in somatomotor and frontoparietal networks compared to adults. SFC increased extensively and fastest in visual and limbic networks.
Impact: This study fills a gap in the SFC research during early development. Our findings characterized the brain connectome in term- and preterm-born neonates, revealing that visual regions developed earlier than somatomotor regions.
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