Abstract #2463

Investigation and validation for cortical laminar structures of myelin and iron using χ-separation (chi-separation)

Byeongpil Moon¹, Hyeong-Geol Shin^2,3, Jiye Kim¹, Sooyeon Ji¹, Chungseok Oh¹, and Jongho Lee¹

¹Department of Electrical Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

Keywords: Susceptibility/QSM, Susceptibility, Gray Matter/ Ex-Vivo Applications

Motivation: Previous studies have demonstrated the correlations between iron and paramagnetic susceptibility and myelin and diamagnetic susceptibility. However, there has yet to be a quantitative layer-wise comparison with histology.

Goal(s): Our objective is to validate laminar structures of χ-separation against histology in V1.

Approach: In V1, we performed laminar profiling of χ-separation, iron-, and myelin histology. The profile was obtained by sampling points at 5% intervals along the cortical depth, oriented perpendicularly to the cortex.

Results: The cortical depth profile reveals that both χ_para with iron histology and χ_dia with myelin staining exhibit similar profiles and peaks at the location of the Gennari line.

Impact: By comparing the cortical depth profile in the V1 region including the location of the Gennari line between χ-separation and histology, we have confirmed that χ-separation (χ_para, χ_dia) accurately represents the quantitative amounts of iron and myelin with precision.

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