Abstract #2515

Fast Single-Point Macromolecular Proton Fraction Mapping using a 0.3 T MRI System

Yasuhiro Fujiwara¹, Shoma Eitoku², Nobutaka Sakae³, Takahisa Izumi⁴, Yuuki Motoyama⁵, Hiroyuki Kumazoe⁵, and Mika Kitajima¹

¹Department of Medical Image Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ²Department of Radiology, Hospital of the University of Occupational and Environmental Health, Fukuoka, Japan, ³Department of Neurology, National Hospital Organization Omuta National Hospital, Fukuoka, Japan, ⁴Department of Radiology, National Hospital Organization Kumamoto Saishun Medical Center, Kumamoto, Japan, ⁵Department of Radiology, National Hospital Organization Omuta National Hospital, Fukuoka, Japan

Synopsis

Keywords: Other Neurodegeneration, CEST & MT

Motivation: Quantifying myelin content in 0.3 T low-field MRI presents a challenge owing to prolonged imaging times and a low signal-to-noise ratio.

Goal(s): The study aimed to validate the practical feasibility of macromolecular proton fraction (MPF) mapping in the brain using a 0.3 T MRI system.

Approach: A phantom study with protein samples and an in vivo investigation were conducted.

Results: The study findings indicate a robust correlation between 0.3 T MPF in brain tissue, MPF at 3.0 T, and previously reported MPF at 0.5 T.

Impact: The fast single-point MPF mapping using a 0.3 T MRI exhibited the capacity to accurately measure brain MPF in a clinically feasible timeframe, providing a valuable tool for assessing myelin content.

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