Abstract #2921

Evaluating R1 and T1w/T2w as myelin-sensitive measures compared to macromolecular proton fraction

Yu Veronica Sui^1,2,3, Pippa Storey^1,2, Alexey Samsonov⁴, and Mariana Lazar^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁴Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Gray Matter, Quantitative Imaging

Motivation: In vivo myelin mapping of the human brain holds great research significance due to the critical role that myelin health plays in both normal and neuropathological conditions.

Goal(s): To quantitatively assess the relationship and concordance between MRI-based myelin-sensitive metrics, which are not well understood in current literature.

Approach: Using the macromolecular proton fraction (MPF) as a standard myelin marker, we compared the longitudinal relaxation rate (R1) and T1w/T2w image ratio and their reliability across tissue types.

Results: We show that R1 corresponds well with MPF across the brain while T1w/T2w is reasonably reliable in only limited areas.

Impact: By quantitatively comparing R1 and T1w/T2w with more established myelin marker MPF, we highlight their varying levels of concordance across tissue types, which informs future studies planning to use R1 or T1w/T2w as myelin proxies in the brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.