Keywords: Visualization, Low-Field MRI, Multiple Sclerosis, Longitudinal, White Matter Lesions
Motivation: Ultra-low-field (ULF) MRI is more patient-accessible due to its cost effectiveness and portability and could in principle allow more frequent follow-up in disabling neurological diseases like multiple sclerosis (MS). However, using ULF MRI to track longitudinal changes is challenging due to reduced SNR and CNR.
Goal(s): To develop an ULF longitudinal subtraction pipeline.
Approach: We developed a subtraction pipeline for ULF images and assessed longitudinal changes in 14 scans from 12 MS participants. Results were compared with an MS neurologist’s impression of high-field images.
Results: Our pipeline was able to detect new lesions and longitudinal changes in MS on par with high-field MRI.
Impact: A longitudinal subtraction pipeline, implemented on ultra-low field MR images, was useful for monitoring interval changes in patients with MS, augmenting the clinical utility of follow-up MRI.
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