Keywords: Multiple Sclerosis, Brain, arterial spin labeling, high field MRI, Atrophy, Perfusion
Motivation: The underlying mechanisms of Multiple Sclerosis (MS) remain unclear, and treatments are lacking. In MS, cerebral atrophy, and impaired cerebral blood flow (CBF), are both aspects of GM pathology.
Goal(s): We aim to assess the relationship between atrophy and CBF in MS, and their changes with disease duration and severity.
Approach: We applied non-invasive ASL-MRI and Atlas-based volumetrics to measure CBF and atrophy in the EAE mouse model of MS, over disease course.
Results: EAE mice showed reduced CBF during peak and long-term disease but atrophy just during long-term disease. Long-term clinical disability and atrophy were correlated with CBF.
Impact: Reduced CBF may relate to pathology in MS, including progression and atrophy. Future studies combining ASL-MRI and atlas-based volumetrics may be useful for investigating the processes underlying neurodegeneration in MS.
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