Keywords: Deuterium, Deuterium, DMI,MRSI,SSFP
Motivation: DMI's faces a poor SNR, and the detection of vital Glx/lactate metabolites in the brain tumor can be compromised.
Goal(s): This research aims to determine whether the optimized CSI-SSFP imaging method is effective for detecting the four biomarkers (HDO, Glucose, Glx, and Lactate) with improved SNR compared to traditional CSI in rodent brains.
Approach: The approach involves comparing DMI SNR using both traditional CSI and CSI-SSFP for monitoring and imaging the metabolism of injected [6,6’-2H2]-glucose in healthy mouse brains.
Results: CSI-SSFP highlights substantial enhancement of 2-3 times in SNR for Glx and lactate.
Impact: DMI is promising to assess the Warburg effect associated with cancer. The CSI-SSFP method provides several folds of SNR improvement, which is critical to improve sensitivity and resolution aiming for imaging intra-tumor heterogeneity and metabolic reprograming in brain tumors.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords