Abstract #3054

Reproducibility of estimating total sodium concentration in the putamen and substantia nigra using sodium MRI at 3T

Peng Liu¹, Naying He¹, Yiming Wang², Yinghua Guo², Zhongping Zhang², and Fuhua Yan^1,3

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Philips Healthcare, Shanghai, China, shanghai, China, ³Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, shanghai, China

Synopsis

Keywords: Non-Proton, Metabolism

Motivation: Brain sodium (²³Na) MRI can provide sodium concentration information in vivo, but there are still some challenges, such as low SNR and relatively low resolution.

Goal(s): To assess the reproducibility of total sodium concentration (TSC) evaluation in the putamen and substantia nigra of healthy individuals using 3D ²³Na MRI.

Approach: Ten healthy subjects were scanned twice consecutively using the 3D TFE UTE and T1W sequence to quantify the TCS in the putamen and substantia nigra. The reproducibility was evaluated.

Results: Concentration of sodium in phantoms can be accurately quantified and TSC in putamen, substantia nigra had good consistency for ²³Na MRI.

Impact: ²³Na-MRI shows potential in becoming a stable and useful biomarker for the diagnosis of patients with neurodegenerative diseases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.