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Abstract #3059

Measuring Tissue-Specific Relaxation Times of Deuterium (2H) Labeled Resonances in the Human Brain at 7T

Viola Bader1, Bernhard Strasser1, Wolfgang Bogner1,2, Lukas Hingerl1, Sabina Frese1, William T Clarke3, Stanislav Motyka1,2, Martin Krššák4, Siegfried Trattnig1,5, Thomas Scherer4, Rupert Lanzenberger6, and Fabian Niess1
1High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, 3Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 5Institute for Clinical Molecular MRI, Karl Landsteiner Society, St. Pölten, Austria, 6Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Deuterium, Deuterium, Relaxation Times, Brain, 7T, Deuterium Metabolic Imaging

Motivation: Deuterium metabolic imaging (DMI) is an emerging Magnetic Resonance technique to non-invasively map the cellular glucose uptake and downstream metabolism. For a reliable concentration estimation, tissue-specific relaxation times are essential, yet only unlocalized relaxation time constants of deuterium labeled resonances are reported.

Goal(s): Measure tissue-specific relaxation times of deuterated resonances (glucose, glutamate+glutamine).

Approach: Inversion recovery and Hahn spin-echo acquisition schemes were implemented into 3D FID 2H-MRSI using concentric ring trajectory readout.

Results: Measured T1 and T2 relaxation time constants of Glc (T1GM=56±14ms; T1WM=60±19ms; T2GM=37±1ms; T2WM=36±2ms) and Glx (T1WM=167±22ms; T1GM=173±12ms; T2GM=36±1ms; T2WM=34±1ms) were not significantly different between GM and WM.

Impact: Many severe brain pathologies feature regional differences in brain glucose metabolism, therefore tissue-specific (grey and white matter) relaxation times (T1 and T2) of deuterium labeled resonances are needed for accurate concentration estimation of the kinetics of energy metabolites (Glc,Glx).

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Abstract

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