Abstract #3091

Enhanced Lateralization of Mesial Temporal Lobe Epilepsy through Vascular Territory Analysis: Insights from Arterial Spin Labeling MRI

Mohammad-Reza Nazem-Zadeh¹, Hossein Rahimzadeh ², Hadi Kamkar ³, Narges Hoseini-Tabatabaei ⁴, Sohrab Hashemi-Fesharaki ⁵, and Jafar Mehvari Habibabadi ⁶

¹Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ²Biomedical Engineering and Medical Physics, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of), ³Bioinformatics and Biophysics, Tarbiat Modares University, Tehran, Iran (Islamic Republic of), ⁴Medical School, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁵Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ⁶Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran (Islamic Republic of)

Synopsis

Keywords: Epilepsy, Perfusion, ASL Perfusion MRI, Lateralization of TLE, Blood Teritorry

Motivation: To enhance lateralization of drug-resistant mesial temporal lobe epilepsy (mTLE) for improved surgery decisions. Using arterial spin labeling (ASL) MRI, this study explores vascular territories to differentiate left and right mTLE.

Goal(s): To assess ASL MRI's potential in distinguishing between mTLE types by studying cerebral blood flow changes.

Approach: It involves comparing mTLE groups to controls using ASL MRI and vascular territory analysis, identifying specific brain regions affecting lateralization.

Results: They highlight vascular territory changes crucial in distinguishing mTLE types, emphasizing the clinical significance of ASL MRI.

Impact: This research may significantly impact treatment decisions, benefitting individuals with challenging mTLE and guiding future epilepsy research.

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