Abstract #3132

Contrast Discrimination in Awake Macaque with 7T MRI

Sunhang Shi^1,2,3, Meixuan Chen^2,3, Chenxi Zhai^2,3, Meizhen Qian^2,3, Jianbao Wang^2,3, Hisashi Tanigawa^2,3, and Anna Wang Roe^1,2,3

¹Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurosurgery of the Second Affiliated Hospital and Interdisciplinary Institute of Neuroscience and Technology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, ³MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based)

Motivation: This research aims to investigate visual perception in awake macaques using 7T MRI, enhancing our comprehension of BOLD responses during a contrast discrimination task and developing a quantifiable method for neuromodulation.

Goal(s): The specific objectives include directly observing BOLD responses at mesoscale during a contrast discrimination task.

Approach: The study utilized 7T MRI while macaques performed a 2AFC task, allowing simultaneous stimulus presentation and BOLD response measurement.

Results: The study successfully mapped BOLD responses during behavioral tasks, revealing contrast sensitivities in the visual cortex. Notably, it identified BOLD signal decreases in ambiguous contrast conditions, shedding light on perceptual uncertainty in stimulus discrimination.

Impact: These findings may advance quantification of behavioral an neural processes, helping to bridged the gap between human non-invasive and monkey invasive studies.

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