Abstract #3133

Functional connectivity of medial pulvinar to limbic system in macaque monkey revealed by INS-fMRI

Yuqi Feng^1,2, Songping Yao^1,2, Sunhang Shi^1,2, Meilan Liu^1,2, Jianbao Wang^2,3, and Anna Wang Roe^1,2,3

¹Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China, ³MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity

Motivation: To understand the circuitry underlying the pulvinar and limbic cortical areas in the brain.

Goal(s): To map at mesoscale functional connections between medial pulvinar (PM) and insular and cingulate cortices in Macaque monkey.

Approach: Infrared neural stimulation was delivered via optic fibers to sequential sites in PM in Macaques and BOLD responses at connected sites mapped in 7T MRI.

Results: We find connectivity of PM with cingulate cortex was patchy and columnar, with sequential sites in PM producing mediolateral topographic activation. A functional topology of these patches was observed in cingulate.

Impact: The specificity and mesoscale nature of functional connections from medial pulvinar to limbic systems, providing new treatment ideas for mental disorders.

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