Abstract #3153

Integrated Resting-state and Breath-hold Paradigm for Reliable Cerebrovascular Reactivity Mapping and Functional Connectivity

Zhanyan Zhang^1,2, Jinyuan Zhang^1,2, Jing An³, Peng Zhang^1,2,4, and Zihao Zhang^1,2,4

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁴Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China

Synopsis

Keywords: Vascular, Vessels

Motivation: There is a lack of head-to-head evaluation of resting-state (RS) and breath-hold (BH) cerebrovascular reactivity (CVR).

Goal(s): Propose an integrated paradigm combining RS- and BH-BOLD acquisition in a single run, and evaluate the reliability of RS- and BH-CVR mapping with this protocol.

Approach: Combined RS- and BH-BOLD data were acquired on a 7T scanner. CVR mappings of various time windows were calculated and compared.

Results: RS-BOLD can be calculated for CVR mapping but is susceptible to BOLD signal outliers. BH-BOLD produces stable CVR mappings with higher dynamic range. The integrated paradigm guarantees reliable BH-CVR mapping and RS-fMRI analysis.

Impact: The introduction of the RS-BH paradigm offers an avenue for reliable CVR mapping with high dynamic range and is compatible with conventional RS-fMRI analysis.

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