Keywords: Contrast Agents, Quantitative Imaging
Motivation: Waste clearance mechanisms are essential to maintain homeostasis of the brain. Impairment of such mechanisms may play a key role in various diseases.
Goal(s): To gain insights into waste clearance processes and propose characteristic metrics to describe them.
Approach: We injected contrast agent intravenously and monitored clearance with serial T1 mapping utilizing fast single-shot T1 acquisition with radial FLASH and NLINV reconstruction in healthy volunteers.
Results: Time-T1 values of full protocol with 35 acquisitions fit well to our exponential model and can be characterized by clearance time $$$\tau$$$ and biggest T1 difference max T1. A dramatically reduced acquisition protocol gives similar results.
Impact: Advanced fast single-shot T1 mapping is promising to characterize waste clearance function in the human brain. Because of a short whole brain acquisition time of 3 minutes it can be integrated easily into existing clinical protocols.
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