Abstract #3262

Echo time optimization of 2HG-edited MRS and T2 determination of tumor metabolites at 3T

Kimberly Chan¹, Rutul Hapani², Elizabeth A Maher^3,4, Toral R Patel⁵, and Anke Henning^1,6

¹The University of Texas Southwestern, Dallas, TX, United States, ²Biomedical Engineering, University of Texas Dallas, Dallas, TX, United States, ³Department of Internal Medicine, The University of Texas Southwestern, Dallas, TX, United States, ⁴Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Department of Neurological Surgery, The University of Texas Southwestern, Dallas, TX, United States, ⁶Max Planck Institute for Biological Cybernetics, Tübingen, Germany

Synopsis

Keywords: Pulse Sequence Design, Cancer, MRS, editing, 2HG, brain, tumor

Motivation: 2HG is an important oncometabolite which is commonly detected using J-difference editing.

Goal(s): Here, we determined the optimal echo time for J-difference editing of 2HG at 3T.

Approach: This was done by evaluating the echo time dependence of the 2HG-edited signal using simulations and in vivo experiments. We also quantified the T2 relaxation of 2HG as well as the co-edited glutamate and glutamine signals

Results: A TE of 90 ms was found to produce the highest signal, however, a TE of 70 ms was found to provide the best separation between 2HG and Glx in poor shimming conditions.

Impact: This optimized J-difference edited sequence could improve MRS measurements of 2HG. This would take MRS one step closer towards clinical applicability which could aid in the diagnosis and treatment monitoring of glioma patients.

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