Abstract #3382

A Spiral, Golden Angle SPGR Sequence for Blood Vessel T1 and T2 Measurement

Troy Umolac^1,2, Sharon Portnoy², Liqun Sun^2,3, Mike Seed^2,3,4, and Christopher K. Macgowan^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁴Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Vascular, Blood

Motivation: Current methods for measuring T1 and T2 in fetal blood are inefficient, which limits their applicability to the largest vessels in late gestation.

Goal(s): To develop a faster, more motion-robust sequence for blood T1 and T2 measurement, which can be applied in fetal subjects.

Approach: A spiral, spoiled gradient echo sequence (sp-SPGR) was developed to jointly estimate blood T1 and T2 from a single, 12 second scan. sp-SPGR accuracy was validated in adult volunteers by comparison with conventional MOLLI and T2p-bSSFP techniques.

Results: The sp-SPGR sequence obtained T1 and T2 estimates consistent with conventional methods in approximately one-fifth the acquisition time.

Impact: As a faster, more motion robust sequence for estimating blood T1 and T2, sp-SPGR will support oximetry measurements in the fetal great vessels at earlier gestational age, facilitating more accurate and timely evaluation of fetal hypoxia.

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