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Abstract #3439

Macroscale angioarchitectural properties of functional and structural networks

Stefano Moia1, Omer Faruk Gulban1,2, Enrico Amico3,4, Maria Giulia Preti3,4,5, Benedikt Poser1, and Dimo Ivanov1
1Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2Brain innovation, Maastricht, Netherlands, 3Neuro-X Institute, École polytechnique fédérale de Lausanne, Geneva, Switzerland, 4Department of Radiology and Medical Informatics (DRIM), University of Geneva, Geneva, Switzerland, 5CIBM Center for Biomedical Imaging, Geneva, Switzerland

Synopsis

Keywords: Functional Connectivity, Multimodal

Motivation: Previous findings from fMRI and from structural microvascular observations link vascular activity or structural organisation with neuronal activity.

Goal(s): To verify whether macrovascular properties are related to functional (FC) and structural connectivity (SC), as well as function-structure coupling (SDI).

Approach: FC and SC node strength, SDI, and vascular density and distance were compared, using a venous atlas, the Human Connectome Project data, and one subject of the Natural Scene Dataset for which we obtained an arteries-dominated vascular map.

Results: Correlations between veins-dominated vascular properties, FC, and SDI, suggest a link between density and proximity of venous structures and connectivity strength of an area.

Impact: Cerebral angioarchitecture is often overlooked in integrated multimodal MRI modelling, but its properties can help understanding the nature of BOLD-fMRI-based “vascular” or “physiological” networks.

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