Keywords: Task/Intervention Based fMRI, fMRI, modeling
Motivation: Understanding the impact of cortical vascular architecture on the spatiotemporal features of hemodynamic responses.
Goal(s): Automatic extraction of realistic cortical vasculature models from microscopy data, and simulation of hemodynamic changes across the extracted vascular network.
Approach: We present a pipeline that utilizes graph theory for extracting the vasculature from microscopy data, representing it as a vascular graph. Simulations were performed using the extracted vascular graphs by converting the connectivity matrix into a dynamic system modeled by RC circuits.
Results: We extracted two realistic vascular graphs and used them to mimic hemodynamic changes resulting from simulated arterial dilation.
Impact: Vascular graphs extracted by the developed pipeline could serve to simulate hemodynamic changes across the cortical vasculature. This provides a tool to enhance fMRI signal interpretation and provide valuable insights into the role of vascular dysfunction in cerebrovascular diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords