Abstract #3615

Intratumoral Habitat and Peritumor Radiomics for Progression Risk Stratification of Patients with Soft Tissue Sarcoma: A Multicenter Study

Hao-yu Liang^1,2, He-xiang Wang², Da-peng Hao², Chuan-ping Gao², Meng Zhang², Qing Li³, Shun-li Liu², Shi-feng Yang⁴, Feng Hou⁵, and Li-sha Duan⁶

¹Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, Shanghai, China, ²Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China, ³MR Collaboration Team, Siemens Healthineers, Shanghai, China, ⁴Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁵Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China, ⁶Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, China

Synopsis

Keywords: Diagnosis/Prediction, Skeletal

Motivation: Increasing the identification accuracy of patients with high risk of progression could help guide treatment decision in soft tissue sarcoma (STS).

Goal(s): To establish a radiomics nomogram that incorporated tumor habitat and peritumor features and validate its performance to predict tumor progression in patients with STS.

Approach: A nomogram combining radiomics based on intratumoral habitat and peritumorwith clinical information was established.

Results: This nomogram predicts tumor progression in STS patients and stratifies them according to the risk of progression.

Impact: Combining radiomics features derived from the intratumoral habitat and peritumoral region resulted in superior performance for predicting progression-free-survival in patients with STS, which is helpful for clinical decision making.

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