Keywords: Microstructure, Brain
Motivation: Diffusion MRI is a promising means to map mesoscopic human brain architecture in vivo, however an appropriate model is required that relates the MR signal and features of the underlying microstructure within the voxel.
Goal(s): The goal of this study is to determine whether a Gaussian diffusion model is applicable at the mesoscale.
Approach: We compared single and double diffusion encoded signals acquired with large b-values at two different diffusion times to test for Gaussianity.
Results: We found no significant time-dependence in the diffusion weighted signals in brain parenchyma, confirming the applicability of the Gaussian diffusion at the mesoscale.
Impact: The study resolves the ongoing debate on the appropriate model to use to analyze the diffusion weighted signals in live human brain at clinically accessible spatiotemporal scales.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords