Abstract #3659

Treatment Monitoring of Irreversible Electroporation in a Potato Model with a two-shot CP/CPMG-RARE Sequence and Spiral Sampling

Othmar Alexander Belker^1,2, Thomas Gerlach^2,3, Max Joris Hubmann^2,4, Oliver Speck^2,5, Frank Wacker^1,2, Bennet Hensen^1,2, and Marcel Gutberlet^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Research Campus Stimulate, Magdeburg, Germany, ³Department of Healthcare Telematics and Medical Engineering, Otto-von-Guericke University, Magdeburg, Germany, ⁴Department of High-Frequency- and Communication Technologies, Otto-von-Guericke University, Magdeburg, Germany, ⁵Department of Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany

Synopsis

Keywords: MR-Guided Interventions, MR-Guided Interventions, Irreversible Electroporation

Motivation: Treatment monitoring of irreversible electroporation (IRE) is only feasible on small animal MRI systems.

Goal(s): Demonstrate Current Density Imaging capabilities of the two-shot CP/CPMG-RARE with spiral sampling by monitoring IRE of a potato in a clinical MR scanner.

Approach: A potato is irreversibly electroporated, while the two-shot CP/CPMG-RARE sequence is acquiring. The electric field is simulated, and the current density is projected using the MRCI toolbox. T1 maps are calculated from inversion recovery sequences.

Results: Simulated and projected current density fields are in good agreement. IRE monitoring in single slices is feasible in clinical MR scanners in optimal conditions.

Impact: Irreversible Electroporation is a promising non-thermal ablation therapy without in-situ validation available. This work presents a step towards implementing treatment monitoring on clinical MR scanners utilizing a two-shot CP/CPMG-RARE with spiral sampling as Current Density Imaging sequence.

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