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Abstract #3683

Measurement of Radiation Effects in Tumor Tissues using MR-based Conductivity Imaging

Ko In Ok1, Choi Bup Kyung2, Park Ji Ae1, Hur Young Hoe3, Kim Hyun Chul4, Kim Jin Woong4, and Kim Hyung Joong2
1Division of Applied RI, Korea Institute of Radiological and Medical Science, Seoul, Korea, Republic of, 2Department of Biomedical Engineering, Kyung Hee University, Seoul, Korea, Republic of, 3Department of Hepato-Biliary-Pancreas Surgery, Chonnam National University Medical School, Gwangju, Korea, Republic of, 4Department of Radiology, Chosun University Hospital and Chosun University College of Medicine, Gwangju, Korea, Republic of

Synopsis

Keywords: Electromagnetic Tissue Properties, Tumor, Ionizing radiation

Motivation: Ionizing radiation produces ions inside the human body that can kill cancerous tissues by damaging DNA directly or creating charged particles that damage DNA.

Goal(s): Contrast mechanism of electrical conductivity is determined by the concentration and mobility of ions that make up tissues.

Approach: We applied MR-based conductivity imaging to mouse brain tumors to evaluate the responses in irradiated and non-irradiated tissues during the peri-irradiation period.

Results: MR-based conductivity images effectively showed acute response after irradiation in glial tumors.

Impact: High-frequency conductivity images can differentiate each brain tissues including viable tumors, tumor necrosis, and normal brain. It shows potential as a tool to differentiate the therapeutic effect of radiation by measuring absolute values and calculating percentage changes.

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