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Abstract #3895

Neurovascular coupling dysfunction of hippocampus-visual network in Post-Concussive Syndrome

Jiahao Yan Yan1 and Jing Zhang1
1Lanzhou University Second Hospital, LanZhou, China

Synopsis

Keywords: Other Neurodegeneration, Arterial spin labelling, post concussion syndrome

Motivation: The clinical relevance and modifications in perfusion and neural activity remain undetermined in Post-Concussive Syndrome.

Goal(s): To delineate changes in NVC during the pathophysiology of PCS, multimodal magnetic resonance imaging was performed on patients and healthy controls.

Approach: Five imaging-markers elucidates the relationship between neuronal activity and perfusion. Dynamic causal modeling evaluates associations with disease transitions, clinical variables, and information flow.

Results: The fALFF-CBF of the hippocampal was diminished, and the ReHo-CBF in the Temporal-Occipital cortex decreased, correlating with declining spatial processing and memory tasks.

Impact: The distinctive pattern of changes in neurovascular coupling in the hippocampal , temporal-occipital cortex provide fresh insights into PCS

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Keywords