Meeting Banner
Abstract #3917

Addressing Gradient Imperfection Related Bias in Stack-of-Stars MRI for Free-Breathing, Confounder-Corrected T1 Mapping

Yavuz Muslu1,2, James H Wang2,3, Ty A Cashen4, Diego Hernando1,2,3,5, Alan McMillan1,2,3, and Scott B Reeder1,2,3,6,7
1Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 4GE Healthcare, Waukesha, WI, United States, 5Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, 6Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: System Imperfections, Relaxometry

Motivation: Non-Cartesian sampling strategies enable free-breathing imaging due to their robustness against motion but are susceptible to artifacts related to gradient imperfections. Such artifacts may manifest as bias or structured noise in quantitative imaging applications.

Goal(s): In this study, we explore the effects of gradient imperfections and evaluate the performance of gradient correction methods in non-Cartesian, confounder-corrected T1 mapping using both phantom and in vivo imaging experiments.

Approach: For this purpose, we compare confounder-corrected T1 maps reconstructed with data-driven and calibration-based gradient correction approaches.

Results: Our initial results indicate that gradient correction methods are essential for mitigating the bias due to gradient imperfections.

Impact: This study confirms that gradient imperfections result in bias in non-Cartesian quantitative imaging applications. Our findings indicate that T1 relaxometry is less susceptible to gradient imperfections than PDFF and R2* quantification. The application of gradient correction methods mitigates this bias.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords