Keywords: Liver, Diffusion/other diffusion imaging techniques, diffusion; perfusion; MR imaging
Motivation: HCCs mostly show higher perfusion values compared with the adjacent normal liver tissue. Paradoxically authors reported a decrease IVIM-PF(perfusion fraction) of HCC relative to adjacent liver.
Goal(s): DWI-derived surrogate biomarker DDVD (diffusion-derived vessel density) is a physiological surrogate of the area of micro-vessels per unit tissue area. This study applied DDVD to assess perfusion of HCC.
Approach: 72 patients were included. DDVD= (signal intensity at b=0)/ROIarea – (signal intensity at b=2/ROIarea).
Results: (tumor DDVD)/(liver DDVD) was 2.942 (median), majority of HCC showing a much higher DDVD than liver.
Impact: DDVD overcome the pitfalls associated with IVIM PF.
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