Keywords: Large Animals, Nonhuman Primates, Preclinical, animal models
Motivation: Functional magnetic resonance imaging is increasingly used to study brain function and cognition in domestic dogs.
Goal(s): The objective of this study was to acquire the high-quality fMRI data which dogs can be trained to remain awake and still inside MRI scanners and detect the pathway for dog’s face processing.
Approach: We use a combination of simulated and real MRI environments to train awake dogs. A visual stimulation paradigm with block design was used to compare activity elicited by human faces against objects.
Results: We successfully detect the activation of human faces against scramble objects in occipitalis, ectomarginalis, and ectosylvius medius.
Impact: This study provides a process for training dogs for fMRI acquisition while awake and introduces the temporal cortex as candidate to process human faces and dog faces.
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