Keywords: Parkinson's Disease, fMRI (resting state), Brain
Motivation: Long-term levodopa treatment can markedly change the brain connectivity network in Parkinson's disease(PD) patients. The changes of static and dynamic brain network in early PD remain unknown.
Goal(s): To investigate the alterations in static and dynamic whole-brain connectivity in early PD patients who have never received dopaminergic therapy.
Approach: A case-control study was performed. The static and dynamic functional connectivity were constructed and analysised.
Results: PD patients showed alterations in the SMN, DGN, LBN, and VSN, which may be relevant to both motor and non-motor symptoms. LEiDA results showed that PD group displayed a shorter lifetime and lower probability than the HC group.
Impact: The study offers neuroimaging evidence of static and dynamic brain functional connectivity changes in drug-naïve early Parkinson's disease patients. It identifies potential biomarkers for clinical Parkinson’s disease diagnosis and assessment.
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