Abstract #4308

Vasculature Assessment of Rhesus Macaque Placental Injury using Variable Flip Angle T1-Mapping and Dynamic Contrast Enhanced MRI

Ruiming Chen¹, Daniel Seiter¹, Jessica Vazquez^2,3, Logan Keding^2,3, Kathleen Antony³, Heather Simmons², Puja Basu², Andres Mejia², Kevin Johnson^1,4, Aleksandar Stanic-Kostic³, Ruo-Yu Liu¹, Dinesh Shah³, Thaddus Golos^2,3,5, and Oliver Wieben^1,4

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Wisconsin National Primate Research Center, University of Wisconsin - Madison, Madison, WI, United States, ³Obstetrics & Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁵Comparative Biosciences, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: Placenta, Placenta

Motivation: A combination of DCE and fractional blood volume analysis could enable better evaluation of local placental injury.

Goal(s): To generate and assess local placental injury for rhesus macaques using Tisseel (fibrin sealant) injections and co-registered contrast arrival time maps and fractional blood volume maps.

Approach: Three rhesus macaques received intraplacental injections of Tisseel to potentially cause tissue ischemia. DCE imaging and variable flip angle T1 mapping were registered and compared qualitatively and quantitatively on a local level.

Results: Possible local placental ischemia observed in both the DCE signal and the blood volume maps. Lower circulating blood volume corresponded regionally to longer arrival times.

Impact: This study successfully creates local placental ischemia that potentially mimics clinical cases seen with fetal growth restriction. The local ischemia could be better visualized using two co-registered MRI methods, thus helping future clinical diagnosis.

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