Keywords: fMRI Analysis, Quantitative Susceptibility mapping, Non-dialysis patients with chronic kidney disease, cognitive decline, neurovascular coupling, arterial spin labeling, functional magnetic resonance imaging
Motivation: The relationship between neurovascular coupling (NVC) dysfunction and cognitive decline in non-dialyzed patients with chronic kidney disease is unclear.
Goal(s): Our goal was to explore the pattern of NVC changes in non-dialysis patients with chronic kidney disease and its relationship with cognitive decline.
Approach: Analyzing neurovascular coupling patterns at the whole-brain and regional levels based on multimodal coupled neuroimaging.
Results: Neurovascular coupling dysfunction associated with cognitive decline in non-dialysis patients with chronic kidney disease.
Impact: Neurovascular coupling may be a potential mechanism for cognitive decline in non-dialyzed patients with chronic kidney disease.
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