Keywords: CEST / APT / NOE, CEST & MT
Motivation: Fitting of CEST spectra is obscured by MT, direct water saturation, and broad fast exchange peaks which result in contamination of quantified signals.
Goal(s): Using AROSE spectra for fitting simplifies CEST quantification by reducing the need for isolation of CEST signals due to preemptive filtering.
Approach: Fitting was first performed on simulated spectra at different exchange rates and then applied to in vivo data.
Results: Our results in MCAO rodents showed that quantification of CEST signal from AROSERRex spectra resulted in low fitting residuals with robust peaks at 3.6, 2.6, and 2 ppm and minimal contamination from MT and fast exchanges.
Impact: Fitting using AROSE-CEST spectra improves quantification of CEST exchange by minimizing contributions from broad fast exchanges and other contaminations such as MT which have been challenges for traditional fitting methods such as multiple -pool Lorentzian fitting.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords