Keywords: CEST / APT / NOE, CEST & MT
Motivation: Creatine and phosphocreatine metabolites imaging at 3T are essential for related disease in muscle.
Goal(s): Estimate creatine proton exchange rate in muscle; Simultaneous mapping of PCr and Cr by PLOF CEST method at 3T.
Approach: Antemortem and postmortem animal study was to validate PCr/Cr CEST peak position and creatine exchange rate. Three types of CEST acquisition methods were compared on human leg muscle.
Results: Z-spectra in mouse hindlimb before and after euthanasia indicated CrCEST is a slow-exchanging process (<150 s-1). This allowed us to simultaneously extract PCr/CrCEST signals and mapping in muscle at 3T using the PLOF method on both human and animal.
Impact: Amide, Cr, and PCr CEST in the skeletal muscle can be mapped simultaneously at 3T by PLOF CEST within a clinically feasible acquisition duration, which has potential to assist in the diagnosis of related diseases.
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