Abstract #4454

A generalized QUCESOP method with evaluating CEST peak overlap

Yi Wang¹, Yang Fan², Xiaolei Song³, and Jia-Hong Gao⁴

¹Public Health Science and Engineering College,Tianjin University of Traditional Chinese Medicine, Tianjin, China, ²MR Research China, GEHealthcare, Beijing, China, ³Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, ⁴Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: When quantifying the CE-parameters (f_b, k_b and R_2b) of the specific CEST solute with existence of other unknown solutes, the peak overlap condition needs to be assessed to evaluate the reliability of the quantification result.

Goal(s): To develop a method for CE-parameters quantification and peak overlap assessment.

Approach: CEST data was acquired with various saturation offsets and powers. When fitting the targeted CE-parameters, the peak overlap was evaluated using RMSE between the trajectories of the acquired and synthesized data. Simulation and experiments were taken to test the performance.

Results: The feasibility of the approach in CE-parameters quantification and peak overlap assessment was verified.

Impact: The proposed method would be helpful for evaluating the reliability of the empirically set model for CE-parameters quantification, and then that of the quantification result.

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