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Abstract #4581

Optimising magnetisation preparation for the 7T FLAIR contrast: simulations and experimental validation

Emilie Sleight1, Antoine Klauser1,2, Gian Franco Piredda1,2, Frédéric Grouiller1,3, Tom Hilbert2,4,5, and Dimitri Van De Ville1,3,6
1CIBM Center for Biomedical Imaging, Geneva, Switzerland, 2Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 3Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 4Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 5LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Pulse Sequence Design, Simulations

Motivation: At ultra-high field, magnetisation preparation should be adjusted to obtain an adequate FLAIR contrast. However, such optimisation of the pulse sequence and comparison between preparation types are missing.

Goal(s): This work aimed to set a simulation framework to investigate the timing of the magnetisation preparation at 7T. T2 and double inversion recovery preparations were compared.

Approach: Various preparation durations were investigated using simulations and measurements on healthy volunteers.

Results: The image contrast obtained under simulation was experimentally validated. The T2-preparation gave the most promising contrast although the pulses were more prone to B0-inhomogeneity artefacts than the ones from the double inversion recovery preparation.

Impact: We demonstrated that an adequate FLAIR contrast at 7T can be obtained by optimising magnetisation preparation. Simulations can be used to improve the sequence, such as optimising the magnetisation preparation and readout in terms of timings and flip angles.

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Keywords