Abstract #4581

Optimising magnetisation preparation for the 7T FLAIR contrast: simulations and experimental validation

Emilie Sleight¹, Antoine Klauser^1,2, Gian Franco Piredda^1,2, Frédéric Grouiller^1,3, Tom Hilbert^2,4,5, and Dimitri Van De Ville^1,3,6

¹CIBM Center for Biomedical Imaging, Geneva, Switzerland, ²Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ³Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, ⁴Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁶Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Pulse Sequence Design, Simulations

Motivation: At ultra-high field, magnetisation preparation should be adjusted to obtain an adequate FLAIR contrast. However, such optimisation of the pulse sequence and comparison between preparation types are missing.

Goal(s): This work aimed to set a simulation framework to investigate the timing of the magnetisation preparation at 7T. T₂ and double inversion recovery preparations were compared.

Approach: Various preparation durations were investigated using simulations and measurements on healthy volunteers.

Results: The image contrast obtained under simulation was experimentally validated. The T₂-preparation gave the most promising contrast although the pulses were more prone to B₀-inhomogeneity artefacts than the ones from the double inversion recovery preparation.

Impact: We demonstrated that an adequate FLAIR contrast at 7T can be obtained by optimising magnetisation preparation. Simulations can be used to improve the sequence, such as optimising the magnetisation preparation and readout in terms of timings and flip angles.

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