Keywords: Liver, Liver
Motivation: T1 and PDFF mapping, which could serve as imaging biomarkers for liver disease, require breath-holds; T1 mapping commonly used in clinical practice, such as MOLLI, has limited spatial coverage. In addition, the presence of liver fat reduces T1 accuracy.
Goal(s): Our goal is to enable simultaneous whole liver water/fat separated T1 and PDFF quantification with clinically acceptable accuracy without breath-holds.
Approach: We introduced the 3D Radial DIXON LL sequence and validated in phantom and in vivo.
Results: Free-breathing 3D Radial Dixon LL sequence results in a proportional bias for T1 measurement and the fixed bias for PDFF measurement compared to current standard techniques.
Impact: The 3D Radial Dixon LL sequence did not result in sufficiently good agreement with reference methods for water/fat separated T1 and PDFF, suggesting that further technical validation and the optimization of imaging parameters will be needed.
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