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Abstract #4779

Accelerated Phase Contrast MRI with Use of K-Space Restoration and Resolution Enhancement Generative Adversarial Neural Network

Manuel A Morales1, Jordan A Street1, Jennifer Rodriguez1, Scott Johnson1, Patrick Pierce1, Warren J Manning1, and Reza J Nezafat1
1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Flow, Cardiovascular

Motivation: Phase-contrast (PC) MRI evaluates blood flow in cardiovascular disease. However, the prolonged scan times limit its efficiency.

Goal(s): We sought to develop a highly accelerated PC technique based on omitting high-frequency k-space regions along the phase encoding direction.

Approach: A deep learning k-space restoration and enhancement strategy for training (KREST) was developed to improve resolution while maintaining phase information. KREST was trained and tested with PC images from 1600 patients.

Results: In a prospective study of 16 patients, KREST reduced breath-hold time relative to parallel imaging (19 vs 6 s).

Impact: Our k-space restoration and enhancement strategy enables resolution-enhancement while providing k-space data consistency. Deep learning accelerated phase-contrast imaging showed similarly accurate quantification of peak mean velocity to a standardized parallel imaging method.

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Keywords