Abstract #4836

Multi-parametric Quantitative Magnetic Resonance Imaging Phantom

Hannah E Alderson^1,2, Scott D Swanson³, William Reichert^1,2, Daniel F Gochberg^2,4, and Mark D Does^1,2,4

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ³Radiology, University of Michigan, Ann Arbor, MI, United States, ⁴Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Phantoms, Phantoms, multiparametric

Motivation: Currently there is no qMRI phantom that simultaneously reproduces the many contrasts that are present in white matter.

Goal(s): The goal of this work is to characterize a single multiparametric qMRI phantom that exhibits diffusion, magnetization transfer and MET₂ properties.

Approach: Aqueous MTF and PVP were combined in varying concentrations and evaluated with both NMR and MRI.

Results: A homogenous, multiparametric qMRI phantom was created with an array of tissue relevant parameters: T_2L ranging from 71.9-183 ms, T_2s ranging from 13.6-17.7 ms, f_s ranging from 0.118-0.177, T_1free ranging from 1479-1919 ms and f_m ranging from 0.053-0.109.

Impact: A multiparametric phantom allows for improved quality assurance analysis, as well as sequence development by allowing for multiple contrasts to be evaluated simultaneously. Ultimately providing a sample that is controlled, yet more akin to what occurs in biological samples.

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